The Indianapolis Colts traded guard Quenton Nelson to the Seattle Seahawks and defensive tackle DeForest Buckner to the San Francisco 49ers on October 27, 2026. The team acquired a 2027 third-round pick and a 2028 fifth-round pick for Nelson, and a 2027 fourth-round pick for Buckner. These transactions occurred during the 2026 NFL season as the team holds a 2-5 record. The moves have prompted analysis regarding the team's roster strategy and future draft capital.